Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis (Cancer Cell, 2010, 17:65-76)

報告日期: 2010/04/16
報告時間: 16:00/16:50
報告學生: 洪君樺(英文報告)
講評老師: 劉校生
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/990416-2.pdf

Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB tumorigenesis

 

Cancerc cell 17, 65-76, 2010

Rinath Jeselsohn, Nelson E. Brown, Lisa Arendt, Ina Klebba, Miaofen G. Hu, Charlotte Kuperwasser,and Philip W. Hinds

 

Speaker: Hung Chun-Hua (洪君樺)

Commentator: Dr. Liu Hsiao-Sheng ( 劉校生老師)    

Date: 16 April, 2010 (16:00 -16:50)

Room: 602, Collage of Medicine

 

Abstract:

    Breast cancer is quite heterogeneous. The cellular origins of breast-cancer-initiating cells have remained obscure. By gene expression profiling analysis, human breast cancers and mouse mammary tumor models have been classified into either luminal-like or basal-like cancers. Among these animal models, MMTV (mouse mammary tumor virus)-Wnt1 tumor model has been shown to classify with human basal-like breast cancer, while MMTV- ErbB2 tumor model with the luminal-type. Transplantation studies have demonstrated the existence of mammary progenitor cells with the ability to selfrenew and regenerate a functional mammary gland. Although these progenitors are the likely targets for oncogenic transformation, correlating progenitor populations with certain oncogenic stimuli has been difficult. It is presumed that different breast cancer subtypes originate from different target populations of breast epithelial cells; however, the identity of these target cells is unclear. According to previous study, Cyclin D1 is required for lobuloalveolar development during pregnancy and lactation as well as MMTV-ErbB2- but not MMTV-Wnt1-mediated tumorigenesis. Using a kinase-deficient cyclin D1 mouse, the authors identified two functional mammary progenitor cell populations, one of which is the target of MMTV-ErbB2. Moreover, they found cyclin D1 activity was required for the self-renewal and differentiation of mammary progenitors. Identification of distinct stem or progenitor cell populations with different hormonal sensitivities and requirements for cyclin D1 activity is appealing because it implies that the cellular origins of certain types of breast cancer may have a similar specificity. These specific requirements among tumor subtypes may provide new therapeutic targets in human breast tumors.

 

Reference:

1. Genome Biol. 8, R76. (2007)

2. Cancer Cell 12, 479-491. (2007)