Stabilization of Snail by NF-kB is required for inflammation-induced cell migration and invasion (Cancer Cell, 2009, 15:416-428)

報告日期: 2010/04/30
報告時間: 17:10/18:00
報告學生: 黃晟協(英文報告)
講評老師: 王育民
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/990430-1.pdf

Stabilization of Snail by NF-kB is required for inflammation-induced cell migration and invasion.

Cancer cell 15, 416-428 (2009)

Yadi, Wu, Jiong Deng, Piotr G. Rychahou, Suimin Qiu, B. Mark Evers, and Binhua P. Zhou.

 

Commentator: Wang, Ju-Ming Ph. D. (王育民老師)

Speaker: Cheng-Hsieh , Huang (黃晟協)

Date: 2010/04/30

Time: 17:10~18:00

place: Room 602

 

Abstract:

Chronic inflammation is one of the most common events in cancer patients. In recent study, the scientists found that tumor-associated macrophages (TAMs) were usually found at the invasive front of more advanced tumors. These cells could promote angiogenesis, extracellular matrix (ECM) breakdown, and tissue remodeling tumor cell motility. However, the underline mechanism of inflammatory cells increased tumor cells motility is still unclear. In this study, the authors found that TNFa, an inflammatory cytokine, could stabilize a transcriptional factor, Snail, via NF-kB signaling pathway to increase cell motility. Moreover, TNFa-mediated Snail stabilization is different from the GSK-3b-induced Snail phosphorylation and proteasome degradation. The authors found that NF-kB could induce the expression of COP9 signalosome 2 (CSN2), in turn, CSN2 could influence the phosphorylation of Snail via blocking the interaction of Snail and GSK-3b. The stabilized Snail could promote tumor cell motility. This study not only reveals a critical mechanism underlying inflammation-induced metastasis but also has important implications in the development of treatment strategies for metastatic cancers.

 

References:

1.  COP9 signalosome: A Multifunctional Regulator of SCF and Other Cullin-Based Ubiquitin Ligases. Cell 114, 663-671 (2003).

2.  Inflammation and Cancer. Nature 420, 860-867 (2002).

3.  Immunity, Inflammation, and Cancer. Cell 140, 883-899 (2010)