Induction of autophagy by spermidine promotes longevity (Nat Cell Biol, 2009, 11:1305-1314)

報告日期: 2010/05/04
報告時間: 15:10/16:00
報告學生: 蕭綾儀
講評老師: 傅子芳
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/990504-1.pdf

Induction of autophagy by spermidine promotes longevity

Nature cell Biology 11, 1305-1314 (2009)

 

Speaker蕭綾儀

Commentator: 傅子芳 老師

Date: 2010/05/04

Classroom602

 

Polyamines such as putrescine, spermidine and spermine are necessary for normal cell growth. Early study showed that a decrease in intracellular polyamine is found in ageing mammalian cell culture. However, the correlation between polyamine and ageing is still unknown. In this article, the authors showed that application of spermidine could extend lifespan in yeast, nematodes, fruit flies and human peripheral blood mononuclear cells. In yeast, they found that spermidine inhibited age-induced necrotic cell death and free radical production. With spermidine, the histone acetylation level is reduced by inhibiting HAT activity. From DNA microarray data, they found that spermidine induced autophagy-related gene expression. In all four species studied, application of spermidine caused autophagy progression. In summary, the spermidine-mediated anti-ageing phenomenon depends on inhibiting global gene expression while promoting autophagy related gene expression.

 

Reference:

1.  Modulation of cellular function by polyamines. The International Journal and Biochemistry& Cell biology 42:39-51 2009

2.  A novel autophagy inducer and longevity elixir. Autophagy 6:106-162 2010