Significance of CD90+ cancer stem cells in human liver cancer (Cancer Cell, 2008, 13:153-166)

報告日期: 2009/04/17
報告時間: 16:00/16:50
報告學生: 梁鎮顯(英文報告)
講評老師: 賴明德
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/980417-2.pdf

Significance of CD90+ Cancer Stem Cells in Human Liver Cancer

Cancer Cell 13: 153–166, 2008

 

Zhen Fan Yang, David W. Ho, Michael N. Ng, Chi Keung Lau, Wan Ching Yu, Patricia Ngai, Patrick W.K. Chu, Chi Tat Lam, Ronnie T.P. Poon and Sheung Tat Fan

 

Speaker: 梁鎮顯

Commentator: 賴明德 老師

Date: 2009/04/17

Time: 16:10-17:00

Room: 602

 

Abstract:

   Hepatocellular carcinoma (HCC) is one of the most common causes of death from cancer. Thus, the isolation and characterization of tumorigenic HCC cells is important to provide novel diagnostic and therapeutic procedures. Cancer stem cells (CSCs), the source of various solid tumors, have been characterized using many stem cell markers. CD90 is a cell surface glycoprotein originally identified on mouse thymocytes and has been identified on a variety of stem cells. CD90 is mainly expressed in leukocytes and is involved in cell-cell and cell-matrix interactions. CD90 has also been reported that expressed in hepatic stem/progenitor cells. Recent studies also shown that CD90 was expressed in various solid tumor types of cancer stem cells. Thus, CD90 may be the potential marker to isolate liver cancer stem cells. This study reveals that CD90 is a potential maker for liver cancer stem cells and the co-expressed with CD44+ enhanced the biological activity of CD90+ cancer stem cells. Inhibition of CD44 activity suppressed CD90+ cell-induced local and systemic tumor formation. These results revealed that CD44 has the therapeutic potential for CD90+ CSCs. Differential gene expression profiles of cancer stem cells and normal stem cells suggest these genes is importantly in hepatocarcinogenesis. The identification of liver cancer stem cells could help us to realize the tumorigenesis of liver cancer and may provide novel diagnostic and therapeutic procedures.

 

Reference:

1.  Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449, 557-563

2.  A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445, 106-110