Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions (Cell Metabolism 2019, 30: 1–18.)

報告日期: 2019/11/29
報告時間: 17:10/18:00
報告學生: 郭宜盈
講評老師: 吳偉立
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Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions

Ip et al., 2019, Cell Metabolism 30, 1–18

Speaker: Yi-Ying Kuok (郭宜盈)    Commentator: Dr. Wei-Li Wu (吳偉立老師)

Time and Date: 17:10-18:00, November 29, 2019

The intake of palatable food can be altered during stress conditions, which indicates a bidirectional relationship between stress and eating [1]. In general, appetite and food intake are controlled by neuropeptide Y (NPY) neurons in the hypothalamus. Interestingly, Npy is highly expressed in the central amygdala (CeA) and its expression could be altered by stress and insulin signaling, which suggest a role of CeA NPY neurons in the regulation of emotion-driven eating [2]. To understand whether NPY neurons in CeA affect feeding after exposure to stress condition, the authors used multiple Npy transgenic mouse models to approach their hypothesis. First, they discovered that stress combined with high-fat diet increased the body weight gain and decreased the energy expenditure. Interestingly, the increase of NPY+ neurons in the CeA was found in mice under stress condition combined with high-fat diet treatment. Specific deletion of Npy in CeA attenuated stress-induced obesity while overexpression of Npy in CeA reversed this phenomenon. Moreover, they found that NPY expression level in CeA was promoted by insulin signal which is evidenced by the genetic ablation of insulin receptor in CeA. Collectively, NPY neurons in CeA regulate the intake of palatable food and stress-induced obesity via insulin signaling.

Keywords: Neuropeptide Y (NPY); Central amygdala (CeA); Food intake; Obesity; Chronic stress conditions

Reference:

  1. Dallman, M.F., et al., Chronic stress and obesity: A new view of "comfort food". Proceedings of the National Academy of Sciences of the United States of America, 2003. 100(20): p. 11696-11701.
  2. Castro, G., et al., Diet-induced obesity induces endoplasmic reticulum stress and insulin resistance in the amygdala of rats. FEBS Open Bio, 2013. 3: p. 443-9.