Adipose-derved circulating miRNAs regulate gene expression in other tissues. (Nature 2017, doi:10.1038/nature 21365))

報告日期: 2017/05/09
報告時間: 15:10/16:00
報告學生: 蔡逸成(以英文報告)
講評老師: 楊尚訓
附件下載: 下載[1655-1488501774-1.pdf] 

Adipose-derived circulating miRNAs regulate gene expression in other tissues

Thomou, T., Mori, M.A., Dreyfuss, J.M., Konishi, M., Sakaguchi, M., Wolfrum, C., Rao, T.N., Winnay, J.N., Garcia-Martin, R., Grinspoon, S.K., et al.

Nature 542, 450–455 23 February, 2017

Speaker: Tsai, Yi-Cheng                 Date: 2017/05/09

Commentator: Prof. Yang, Shang-Hsun     Place: classrooms 602

Abstract

    MicroRNAs are 19-22 nucleotide-long non-coding RNAs, and mature microRNAs are released to circulating systems by exosomes (50-200 nm)(Ryan et al., 2015). The authors found circulating microRNAs decreased in HIV-associated lipodystrophy and congenital generalized lipodystrophy patients. The authors reported this phenomenon and proposed two hypotheses as following. 1. Does adipose tissue regulate circulating microRNAs? 2. Does exosomes RNA regulate genes expression of distant organs? In this article, the authors established AdicerKO mice, whose dicer gene was specificity knock-out in adipose tissue. AdicerKO mice could not release mature mi-RNA in circulating systems. In this article, authors found adipose tissue is a major source of circulating miRNAs and the exosome RNA can travel through circulating systems such as blood vessel to regulate gene expression of distant organs (Thomou et al., 2017).

Reference:

Ryan, B., Joilin, G., and Williams, J.M. (2015). Plasticity-related microRNA and their potential contribution to the maintenance of long-term potentiation. Frontiers in Molecular Neuroscience 8.

Thomou, T., Mori, M.A., Dreyfuss, J.M., Konishi, M., Sakaguchi, M., Wolfrum, C., Rao, T.N., Winnay, J.N., Garcia-Martin, R., Grinspoon, S.K., et al. (2017). Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature 542, 450-455.